We are always open to applications from motivated phd or postdoc candidates. Please send your cv and a motivation letter to marek.bartosovic@dbb.su.se

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We have two open positions for postdocs - one wet lab and one computational. 

 

For general inquires about positions contact PI marek.bartosovic@dbb.su.se​​

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Wet lab postdoc  

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We are seeking a highly motivated postdoctoral researcher to investigate the molecular mechanisms of brain evolution. This project focuses on how non-coding regulatory elements shape brain development and evolution, and how species-specific changes may contribute to cell identity and functions relevant for human cognition. 

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Using cutting-edge single-cell and spatial epigenomic approaches, combined with reporter assays, CRISPR/Cas9 and in vitro brain organoid models from human and non-human primates, the postdoc will identify and functionally characterize species-specific regulatory elements and their roles in neurodevelopmental programs. This work will advance our understanding of what makes the human brain unique and may provide insight into neurodevelopmental disorders, including autism spectrum disorder and schizophrenia.

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Main responsibilities

-       Culture and maintenance of human pluripotent stem cells (iPSC/ESC)

-       Development and implementation of 2D and 3D models of human brain development

-       Implementation of reporter assays (MPRA) at bulk and single-cell level with possibility for method development.

-       Work with human tissue, sectioning, immunohistochemistry, RNAscope or other in-situ RNA hybridization

-       Genome/epigenome editing using CRISPR-based methods

-       Application of advanced single-cell, multimodal, and spatial epigenome profiling technologies

-       Collaboration with other members of the research group

-       Supervision of MSc and PhD student projects

-       Writing reports, manuscripts, and documentation

-       Preparation of presentations and participation in international conferences

We are looking for a motivated and enthusiastic postdoctoral researcher with a strong interest in gene regulation, single-cell technologies and background in either of stem cell, neuroscience fields and/or genomics/molecular biology. Applicants are expected to hold a Swedish doctoral degree or an equivalent degree from another country. The candidate should have a competitive publication record.

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The expected starting date is summer 2026 and is negotiable.

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For application send your CV and cover letter to louise.lehto@dbb.su.se

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Computational postdoc

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We are seeking a highly motivated computational postdoctoral researcher to investigate the molecular mechanisms of brain evolution. This project focuses on how non-coding regulatory elements shape brain development and evolution, and how species-specific changes may contribute to advanced cognitive traits.

The postdoc will develop computational strategies to investigate gene regulation & epigenetics in human fetal brain development and in brain evolution, combining multi-omic data (e.g., sc/snRNA-seq, ATAC-seq, CUT&Tag/ChIP-type profiles (multi-omic), spatial where relevant) with deep learning to model regulatory logic and developmental trajectories.

The project will be focused on regulatory programs across human cortical development
 

-       Routine analysis and integration of multi-omic single-cell epigenomic datasets

-       enhancer–gene linking / GRNs / cis-regulatory grammar

-       linking TFs to specific regulatory elements

-       elucidating how rewiring of TFs changed in primate brain evolution.

-       sequence + chromatin-informed models (foundation models, multimodal deep learning, sequence2function models)

-       tight loop between computational discovery and biological insight

We are looking for a motivated and enthusiastic postdoctoral researcher with a strong interest in gene regulation, single-cell technologies and strong background in computational data analysis. Applicants are expected to hold a Swedish doctoral degree or an equivalent degree from another country. The candidate should have a competitive publication record.

The expected starting date is summer 2026 and is negotiable.​

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For application send your CV and cover letter to louise.lehto@dbb.su.se

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Applications from perspective PhD students or research assistants are also welcome.

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We currently have open positions for master thesis on following topics:

- Multimodal mapping of chromatin in human fetal tissue
- Human brain evolution and HARs 

- Cerebellum development in autism spectrum disorder 

- High-throughput mapping of transcription factors binding sites 

- DNA methylation in human brain development